Multiplication
A. Monomial by Monomial:
Multiply numerical coefficients together, then apply the product law of exponents ($x^m \times x^n = x^{m+n}$):
$$(-4x^2y) \times (3xy^3) = (-4 \times 3) \times (x^2 \cdot x) \times (y \cdot y^3) = \mathbf{-12x^3y^4}$$
B. Polynomial by Polynomial:
Multiply every term of the first polynomial by every term of the second (the Distributive Law):
$$(2x - 3)(4x^2 + 5x - 6) = 2x(4x^2 + 5x - 6) - 3(4x^2 + 5x - 6)$$
$$= (8x^3 + 10x^2 - 12x) - (12x^2 + 15x - 18)$$
$$= 8x^3 + 10x^2 - 12x - 12x^2 - 15x + 18 = \mathbf{8x^3 - 2x^2 - 27x + 18}$$